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Acyclovir in the management of chickenpox MCN Am J Matern Child Nurs. Treatment of chickenpox with oral acyclovir appears to decrease the number of pox lesions and shorten the duration of new lesion formation. Antibody response was unaffected. Treatment with oral acyclovir should be considered for varicella in adults who are identified within the first 24 hours of exanthem. The pka’s of acyclovir, USP are 2. Acyclovir, USP is a white, crystalline powder with the molecular formula C 8 H 11 N 5 O 3 and a molecular weight of 225. It is commonly used for the diagnosis or treatment of Cold sores, infections of skin, eye, genitals, chickenpox, varicella-zoster virus. Acyclovir Ointment is a Ointment manufactured by Jan Aushadhi. In a double-blind placebo-controlled trial, children who had varicella of recent onset received either acyclovir or placebo. Publication types Clinical Trial Controlled Clinical Trial. The maximum solubility in water at 37°C is 2. Side effects of acyclovir were few Conclusions: Acyclovir is a safe treatment that reduces the duration and severity of chickenpox in normal children when therapy is initiated during the first 24 hours of rash. In immunocompetent children, varicella is usually not a serious disease, but can cause severe morbidity and mortality in adults and in immunocompromised individuals. Similarly, herpes zoster is associated with much greater morbidity. Patients treated with acyclovir fared better in number of lesions, duration of onset of new lesions, time to healing, and duration of fever and malaise. Whether treatment with acyclovir can reduce the rare, serious complications of chickenpox remains uncertain. Publication types Comparative Study MeSH terms Acyclovir / administration & dosage Acyclovir / therapeutic use* Administration, Oral Adolescent Adult Chickenpox / drug therapy* Female Follow-Up Studies Humans Male. It has some side effects such as Application site pain, Application site tingling, Irritation, Skin inflammation Each gram of acyclovir ointment, USP 5% contains 50 mg of acyclovir, USP in a polyethylene glycol (PEG) base. It is also used to prevent having regular outbreaks of genital herpes. Primary infection caused by varicella-zoster virus (VZV) is manifest by varicella (chickenpox), while reactivation of latent virus causes herpes zoster (shingles). Acyclovir will not get rid of the virus infection but does help sores heal faster and helps with pain relief.

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